Neuro 215: Brain Imaging and Brain Stimulation
Course Directors: Marco Iacoboni, MD PhD, Shantanu Joshi, PhD, David Shattuck, PhD
Quarter: Spring 2021
Time: Tuesdays, 1pm-2:15pm (Online)
CCLE Website: https://ccle.ucla.edu/course/view/21S-NEURO215-11
Description:
Introduction to the fields of brain imaging and brain stimulation, various imaging modalities, and neurostimulation strategies. Introduction to the use of imaging in isolation or in combination with stimulation to understand neural circuitry, systems and networks in health and disease. Encourages critical thinking about the opportunities and limitations of the two fields, and how to overcome them by combining the two approaches for the investigation of brain systems and functions.
Grading:
S/US
Assigned Reading:
We will assign papers each week focused on the lecture topics. These will be added to this website once assigned.
Lectures
| Week | Date | Topic | Instructor |
|---|---|---|---|
| 1 | 03/30/2021 | Course Introduction / Neuroanatomy | David Shattuck, PhD / Allan MacKenzie-Graham, PhD |
| 2 | 04/06/2021 | Magnetic Resonance Image Formation | Shantanu Joshi, PhD |
| 3 | 04/13/2021 | Structural and Diffusion MRI | David Shattuck, PhD |
| 4 | 04/20/2021 | Positron Emission Tomography (PET) Imaging | Roger Woods, MD |
| 5 | 04/27/2021 | Deep Brain Stimulation (DBS) | Emily Mankin, PhD |
| 6 | 05/04/2021 | Functional MRI (fMRI) | Martin Monti, PhD |
| 7 | 05/11/2021 | Transcranial Direct Current Stimulation (tDCS) | Mayank Jog, PhD |
| 8 | 05/18/2021 | Transcranial Magnetic Stimulation (TMS) | Marco Iacoboni, MD PhD |
| 9 | 05/25/2021 | Transcranial Ultrasound (tUS) | Taylor Kuhn, PhD |
| 10 | 06/01/2021 | Students presentations |
Reading
- Neuroanatomy
- Magnetic Resonance Image Formation
- Logothetis, NK (2001) Neurophysiological investigation of the basis of the fMRI signal Nature 412:150–157. https://www.nature.com/articles/35084005
- Le Bihan D (2003) Looking into the functional architecture of the brain with diffusion MRI Nature Reviews Neuroscience 4:469–480. https://doi.org/10.1038/nrn1119
- Structural and Diffusion MRI
- Jbabdi S (2009) "Chapter 21 - Imaging Structure and Function", Editor(s): Heidi Johansen-Berg, Timothy E.J. Behrens, Diffusion MRI, Academic Press, 2009, pp461-480, https://doi.org/10.1016/B978-0-12-374709-9.00021-3.
- Tournier J-D, Mori S, Leemans A (2011) Diffusion Tensor Imaging and Beyond Magnetic Resonance in Medicine 65:1532–1556 https://doi.org/10.1002/mrm.22924
- Positron Emission Tomography (PET) Imaging
- Badawi RD, Shi H, Hu P, Chen S, Xu T, Price PM, Ding Y, Spencer BA, Nardo L, Liu W, Bao J, Jones T, Li H, Cherry SR. First Human Imaging Studies with the EXPLORER Total-Body PET Scanner (2019) Journal of Nuclear Medicine 60(3):299-303. https://doi.org/10.2967/jnumed.119.226498
- Tripathi SM, Murray AD (2021) Alzheimer’s Dementia: The Emerging Role of Positron Emission Tomography Neuroscientist 2021 Mar 4 ;1073858421997035 https://doi.org/10.1177/1073858421997035
- Deep Brain Stimulation (DBS)
- Mankin EA and Fried I (2020) Modulation of human memory by deep brain stimulation of the entorhinal-hippocampal circuitry Neuron 106.2 (2020): 218-235. https://doi.org/10.1016/j.neuron.2020.02.024
- Titiz AS, Hill MRH, Mankin EA, Aghajan ZM, Eliashiv D, Tchemodanov N, Maoz U, Stern J, Tran ME, Schuette P, Behnke E, Suthana NA, Fried I (2017) Theta-burst microstimulation in the human entorhinal area improves memory specificity Elife 2017;6:e29515. https://doi.org/10.7554/eLife.29515.001
- Functional MRI (fMRI)
- Monti MM (2011) Statistical analysis of fMRI time-series: a critical review of the GLM approach Front. Hum. Neurosci. 18 March 2011; 5:28 https://doi.org/10.3389/fnhum.2011.00028
- Crone JS, Lutkenhoff ES, Bio BJ, Laureys S, Monti MM (2016) Testing Proposed Neuronal Models of Effective Connectivity Within the Cortico-basal Ganglia-thalamo-cortical Loop During Loss of Consciousness Cerebral Cortex 27(4)2727-38 https://doi.org/10.1093/cercor/bhw112
- Transcranial Direct Current Stimulation (tDCS)
- Nitsche MA, Paulus W (2000) Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation Journal of Physiology 527.3:633–9. http://dx.doi.org/10.1111/j.1469-7793.2000.t01-1-00633.x
- Jog MS, Kim E, Anderson C, Kubicki A, Kayathi R, Jann K, Yan L, Leaver A, Hellemann G, Iacoboni M, Woods RP, Wang DJJ, Narr KL (2021) In-vivo imaging of targeting and modulation of depression-relevant circuitry by transcranial direct current stimulation: a randomized clinical trial Translational Psychiatry 11(1):138. https://doi.org/10.1038/s41398-021-01264-3
- Transcranial Magnetic Stimulation (TMS)
- Paus T, Sipila PK, Strafella AP (2001) Synchronization of Neuronal Activity in the Human Primary Motor Cortex by Transcranial Magnetic Stimulation: An EEG Study Journal of Neurophysiology 86(4): 1983–90. http://dx.doi.org/10.1152/jn.2001.86.4.1983
- Strafella AP, Paus T, Barrett J, and Dagher A (2001) Repetitive Transcranial Magnetic Stimulation of the Human Prefrontal Cortex Induces Dopamine Release in the Caudate Nucleus The Journal of Neuroscience 21(15):RC157. http://dx.doi.org/10.1523/JNEUROSCI.21-15-j0003.2001
- Transcranial Ultrasound (tUS)
- Badran BW, Caulfield KA, Stomberg-Firestein S, Summers PM, Dowdle LT, Savoca M, Li X, Austelle CW, Short EB, Borckardt JJ, Spivak N, Bystritsky A, George MS (2020) Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled study. Brain Stimulation 13(6):1805–12. http://dx.doi.org/10.1016/j.brs.2020.10.007
- Folloni D, Verhagen L, Mars RB, Fouragnan E, Constans C, Aubry J-F, Rushworth MFS, Sallet J (2019) Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation. Neuron 101(6):1109–16.e5. http://dx.doi.org/10.1016/j.neuron.2019.01.019
- Magnetic Resonance Image Formation